Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450, Ugts, P-Glycoproteins (Concise Guides) - Softcover

The long-awaited Second Edition of this best-selling Concise Guide is here. Like the first edition of this unique pocket reference, the second edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive website references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, drug interaction assessment and prescribing guidelines, and medicolegal issues.

Following Part I, a succinct review of pharmacology, Part II contains pertinent tables, short reviews, and carefully chosen clinical and research illustrations (with case vignettes) for each P450 enzyme. In Part III, unique to this guide, the drugs used commonly in nonpsychiatric medicine that have clinically significant pharmacokinetic phase I, phase II, or P-glycoprotein drug interactions are arranged by specialty and listed in tables. Part IV focuses on practical matters, with chapters on drug interaction assessment and prescribing guidelines, medicolegal issues, and review and retrieval of the literature.

To enhance clinicians' use of this guide as a quick reference, the authors provide a pocket guide to the most common and potent inhibitors and inducers of drug metabolism, by enzyme system and by medical specialty.

Designed to enable psychiatrists to develop individualized tables and references for their own practices, this concise "how-to" guide will prove indispensable for students and practitioners in psychiatric (especially in complicated medical/surgical settings, such as geriatrics) and nonpsychiatric (primary care, family practice, internal medicine, and obstetrics/gynecology) specialties alike.

Kelly L. Cozza, M.D., is a Psychiatrist at the Infectious Disease Service, Department of Medicine, at the Walter Reed Army Medical Center in Washington, D.C.; Assistant Professor at the Department of Psychiatry, Uniformed Services University of the Health Sciences in Bethesda, Maryland; and Fellow of the Academy of Psychosomatic Medicine. Dr. Cozza is the Med-Psych Drug-Drug Interactions Update co-editor of Psychosomatics.

Scott C. Armstrong, M.D., is Co-Medical Director at the Center for Geriatric Psychiatry, Tuality Forest Grove Hospital in Forest Grove, Oregon; Clinical Associate Professor of Psychiatry at Oregon Health and Science University in Portland; and Fellow of the American Psychiatric Association and the Academy of Psychosomatic Medicine. He has published many articles on various psychiatric subjects and is a peer reviewer for Military Medicine and Psychosomatics, as well as the Med-Psych Drug-Drug Interactions Update Editor of Psychosomatics.

Jessica R. Oesterheld, M.D., is Medical Director of The Spurwink School in Portland, Maine, and an Instructor in Family Medicine at the University of New England School of Osteopathy in Biddeford, Maine.